The website was redesigned providing new query options.īRENDA (BRaunschweig ENzyme DAtabase ), the major public information system for functional and molecular properties of enzymes, celebrated its 25th anniversary in 2013. The EnzymeDetector genome annotation tool and the reaction database BKM-react including reactions from BRENDA, KEGG and MetaCyc were improved. Word Maps for enzymes obtained from PubMed abstracts highlight application and scientific relevance of enzymes. The human anatomy atlas CAVEman is linked to the BRENDA Tissue Ontology terms providing a connection between anatomical and functional enzyme data. New features improving the functionality and analysis tools were implemented. Functional and structural data of more than 190 000 enzyme ligands are stored in BRENDA. They are complemented by information on occurrence, enzyme/disease relationships from text mining, sequences and 3D structures from other databases, and predicted enzyme location and genome annotation. Each entry is connected to the literature reference and the source organism. The manually derived core contains 3 million data from 77 000 enzymes annotated from 135 000 literature references. Approximately 300 million data include enzyme function and molecular data from more than 30 000 organisms.
The information is obtained by manual extraction from primary literature, text and data mining, data integration, and prediction algorithms. The BRENDA enzyme information system ( ) has developed into an elaborate system of enzyme and enzyme-ligand information obtained from different sources, combined with flexible query systems and evaluation tools.
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